51.2% in the nicotine-replacement group) and nausea more frequently in the nicotine-replacement group (37.9%, vs. Overall, throat or mouth irritation was reported more frequently in the e-cigarette group (65.3%, vs. Among participants with 1-year abstinence, those in the e-cigarette group were more likely than those in the nicotine-replacement group to use their assigned product at 52 weeks (80% vs. The 1-year abstinence rate was 18.0% in the e-cigarette group, as compared with 9.9% in the nicotine-replacement group (relative risk, 1.83 95% confidence interval, 1.30 to 2.58 P<0.001). ResultsĪ total of 886 participants underwent randomization. Secondary outcomes included participant-reported treatment usage and respiratory symptoms. Participants who were lost to follow-up or did not provide biochemical validation were considered to not be abstinent. The primary outcome was sustained abstinence for 1 year, which was validated biochemically at the final visit. Treatment included weekly behavioral support for at least 4 weeks. National Health Service stop-smoking services to either nicotine-replacement products of their choice, including product combinations, provided for up to 3 months, or an e-cigarette starter pack (a second-generation refillable e-cigarette with one bottle of nicotine e-liquid ), with a recommendation to purchase further e-liquids of the flavor and strength of their choice. We randomly assigned adults attending U.K. The most trusted, influential source of new medical knowledge and clinical best practices in the world.Į-cigarettes are commonly used in attempts to stop smoking, but evidence is limited regarding their effectiveness as compared with that of nicotine products approved as smoking-cessation treatments. Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community. The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care. NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making.
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January 2023
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